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Professor Ozone

Medical Ozone Therapy

We would like to introduce ourselves as the oldest Medical Ozone center in Malaysia, First to Provide Ground - Breaking Therapy in Treatment and Prevention of Coronary Artery Disease. We are the certification and educational body for the therapies listed below world-wide. To date we have trained and certified more than 1000 doctors in this incredible modality. It is our hope to certify even more physicians in the following years to ensure that this therapy earns it's rightful place in Modern Medicine.

RHP/EBOO SAFE - has set a benchmark, by its self-recognition in playing the key role in the treatment and Prevention of Coronary Artery Disease. No Cardiologist, Medical Professional, or Coronary Heart Disease Patient can afford to ignore this vital role RHP/EBOO SAFE.

As a leader in the discovery, research, development, manufacture, training, certification and marketing of RHP/EBOO SAFE, we are committed to improving health and well-being through innovative treatment, products and services. We share the medical world's goal of bringing safer and more effective products to the market as promptly as possible.

Before we introduce our treatment, products and services, allow us to give a brief about ozone therapy which began in 1870 in Germany and now approved in more than 25 countries all around the world including Germany, Italy, Japan, Austria, Switzerland, Cuba and some states in the US plus many more. There are 2,000 ozone clinics in Europe alone.

The therapeutic use of ozone has an excellent safety record and no toxic effects have been observed from proper clinical use. The use of ozone as a healing adjunct is well established and is being vigorously pursued by many scientists and clinicians. The benefits are predictable and without side effects. As technology advances, undoubtedly new techniques will enlarge the scope of the effective use of this versatile modality.

Now let us introduce our main topic- RHP/EBOO SAFE, the therapeutic ozoniser, an equipment that produces automatically different ozone concentrations in continuous and reproducible ways in all of ozone's therapeutic ranges.

It can be used in all ozone medical applications known at present, for example, optic neuropathy, chronic glaucoma, cochleovestibular syndrome, retinitis pigmentosa, senile dementia, sickle cell anemia, sepsis prevention, arthorosis, obliterant arteriopathy, ulcers of the limb, diabetic foot, radiological contrast in diaphragmatic angiography. In general, in the specialties of ophthalmology, geriatrics, orthopedics, angiology and internal medicine.

RHP/EBOO SAFE are the names of the ozone generators. As the function implies, RHP/EBOO SAFE generates ozone upon introduction of medical oxygen into the unit. Our procedure, known as RHP/EBOO (Recuirculatory Haemoperfusion and Extracorporeal Blood Oxygenation and Ozonation) is similar to haemodylisis. In this case, RHP/EBOO is born as remedy to many cardiological problems, without undergoing the threatening high risk, painful, expensive and complicated procedures of surgery.

Specialized ozone therapy centers, on administrating the non- invasive therapy RHP/EBOO SAFE to severe coronary artery disease patients, have found amazing results.

Through years of extensive research, we have developed an apparatus called RHP/EBOO SAFE that facilitates to treat 3 to 4 liters of blood with medical ozone in extracorporeal circulation for a period 60 to 90 minutes of patients with coronary heart disease. RHP/EBOO SAFE has proven to be second to none in delivering its role in the procedural assay of safe straight to the heart therapy.

To achieve satisfactory result, one has to undergo 5 to 35 hours therapy depending on the state of the disease.

RHP/EBOO SAFE is performed by withdrawing venous blood and then the same blood is infused into an oxygen-ozone gas exchange filter in and upward direction, using a specialized guideline with a computerized peristaltic pump controlling the rate of withdrawal. Medical ozone from the unit is introduced into this hydrophobic and ozone resistant gas exchange filter in the opposite direction from top going downwards and ozonation of blood begins. To avoid coagulation during the process of RHP/EBOO SAFE treatment, heparinazation of the blood is done (but not absolutely necessary as there are other means) just before the blood is infused into the filter. After passing through the oxygen-ozone gas exchange filter, treated,filtered blood is re-infused in to the patient. Upon establishment of extracorporeal circuit, the withdrawal rate will be increased to a range of 60-80 ml per minute, depending on the condition of the patient until the therapy is complete.


It has been established by various scientific researchers that reinfusion oxygenated and ozonated blood enhances the release of nitric oxide and interleukin-8 in the human endothelial cells (the layer of cells lining on the artery wall).

Achieved results of the therapy in general from various conditions of patients shows:

1. Improved Vasodilatation (stretching of a vessel/arteriole beyond its normal dimension leading to increased blood flow) in ischemic areas.

2. Reduced hypoxia (reduction of oxygen carrying capacity of blood)

3. Induced Neoangiogenesis (formation of new blood vessels) due to enhanced release of nitric oxide.

The results of what has been outlined above not only achieve tremendous results in patients with any frm of vascular disese but as well begin to act and restore many functions of the organs due to the increase in vascular flow throughout the body. One can only imagine the possibilities of this type of therapy when used on other disorders and issues associated with the human body.


SAFE is a device-based therapy intended to remove extra fluid from blood and body ; Simple Access Fluid Extraction (SAFE) as the name implies. Patients with heart failure typically are treated with various medications, including angiotensin-converting enzyme inhibitors, beta-blockers, diuretics, and inotropic drugs. Although these drugs don't stop disease progression, they may reduce symptoms and improve functional capacity. Over time, however, some patients stop responding to these therapies.

SAFE , a process that removes fluid from the intravascular compartment, can help ease symptoms for these patients. It may even help patients respond again to conventional drug therapy.

During SAFE, the patient intravascular fluid remains stable, as fluid shifts from extravascular space that lost from the vessels. This reduces edema and third spacing. But because fluid is not removed from the vascular compartment any faster than it can be recruited from the peripheral tissues, patients do not become hypotensive- the plasma refilling rate is adequate to prevent hypovolemia. The patient's heart rate, blood pressure and serum electrolytes also remain largely unchanged.

In general, SAFE improves the quality of life with the ceasing of anginal pain and increase of functional abilities. We are proud to say that SAFE is a truly high quality Malaysian invention by a team of medical experts and engineers.

We would also like to dedicate our sincere appreciation to the 1998 Nobel Prize Winners in Physiology or Medicine for their discoveries concerning nitric oxide as a signaling molecules in the cardiovascular system- Robert F. Furchgott (SUNY Health Science Center Brooklyn, New York, USA), Louis J. Ignarro (University of California School of Medicine) and Ferid Murad (University of Texas) for their discoveries concerning the role of nitric oxide as a signaling molecule in the cardiovascular system. These medical experts have given us the inspiration and encouragement to come up with our invention SAFE.

Should you wish to become a patient or learn more about this technology, please send an email to

May God Bless You And Keep You Well

Peter "Professor Ozone" Jovanovic

Ozone Hospital Motto

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